Mycobactin Explained

Mycobactin is a siderophore used by members of the genus Mycobacterium to shuttle free extracellular iron ions into the cytoplasm of mycobacterial cells.[1] The pathogen M. tuberculosis can synthesize its own mycobactin for this purpose, however there are other mycobacteria such as M. avium subspecies paratuberculosis that cannot produce this siderophore and thus it must be supplied to cultivate this organism in the lab or in host organism.[2] [3]

Notes and References

  1. Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis. Journal of Bacteriology . 194. 11. 2809–18. 10.1128/JB.00088-12 . 22447909. 2012. McMahon. M. D.. Rush. J. S.. Thomas. M. G. . 3370630.
  2. Lack of mycobactin dependence of mycobacteria isolated on Middlebrook 7H11 from clinical cases of ovine paratuberculosis. Veterinary Microbiology. 45. 2–3. 211–7. 10.1016/0378-1135(95)00037-B. 7571372. 1995. Adúriz. J.J.. Juste. R.A.. Cortabarria. N..
  3. Dane . Hannah . Stewart . Linda D . Grant . Irene R . 2022-12-13 . Culture ofMycobacterium aviumsubsp.paratuberculosis: challenges, limitations and future prospects . Journal of Applied Microbiology . 134 . 1 . 10.1093/jambio/lxac017 . 1365-2672.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mycobactin".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.