| Motor neuron disease | |
| Field: | Neurology |
Motor neuron diseases or motor neurone diseases (MNDs) are a group of rare neurodegenerative disorders that selectively affect motor neurons, the cells which control voluntary muscles of the body.[1] They include amyotrophic lateral sclerosis (ALS),[2] [3] progressive bulbar palsy (PBP), pseudobulbar palsy, progressive muscular atrophy (PMA), primary lateral sclerosis (PLS), spinal muscular atrophy (SMA) and monomelic amyotrophy (MMA), as well as some rarer variants resembling ALS.
Motor neuron diseases affect both children and adults. While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness. Most of these diseases seem to occur randomly without known causes, but some forms are inherited. Studies into these inherited forms have led to discoveries of various genes (e.g. SOD1) that are thought to be important in understanding how the disease occurs.[4]
Symptoms of motor neuron diseases can be first seen at birth or can come on slowly later in life. Most of these diseases worsen over time; while some, such as ALS, shorten one's life expectancy, others do not. Currently, there are no approved treatments for the majority of motor neuron disorders, and care is mostly symptomatic.
Signs and symptoms depend on the specific disease, but motor neuron diseases typically manifest as a group of movement-related symptoms.[5] They come on slowly, and worsen over the course of more than three months. Various patterns of muscle weakness are seen, and muscle cramps and spasms may occur. One can have difficulty breathing with climbing stairs (exertion), difficulty breathing when lying down (orthopnea), or even respiratory failure if breathing muscles become involved. Bulbar symptoms, including difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and excessive saliva production (sialorrhea), can also occur. Sensation, or the ability to feel, is typically not affected. Emotional disturbance (e.g. pseudobulbar affect) and cognitive and behavioural changes (e.g. problems in word fluency, decision-making, and memory) are also seen. There can be lower motor neuron findings (e.g. muscle wasting, muscle twitching), upper motor neuron findings (e.g. brisk reflexes, Babinski reflex, Hoffman's reflex, increased muscle tone), or both.
Motor neuron diseases are seen both in children and adults. Those that affect children tend to be inherited or familial, and their symptoms are either present at birth or appear before learning to walk. Those that affect adults tend to appear after age 40. The clinical course depends on the specific disease, but most progress or worsen over the course of months. Some are fatal (e.g. ALS), while others are not (e.g. PLS).
Various patterns of muscle weakness occur in different motor neuron diseases. Weakness can be symmetric or asymmetric, and it can occur in body parts that are distal, proximal, or both. According to Statland et al., there are three main weakness patterns that are seen in motor neuron diseases, which are:[6]
Motor neuron diseases are on a spectrum in terms of upper and lower motor neuron involvement. Some have just lower or upper motor neuron findings, while others have a mix of both. Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal reflexes.
Pure upper motor neuron diseases, or those with just UMN findings, include PLS.[7]
Pure lower motor neuron diseases, or those with just LMN findings, include PMA.[8]
Motor neuron diseases with both UMN and LMN findings include both familial and sporadic ALS.[9]
Most cases are sporadic and their causes are usually not known. It is thought that environmental, toxic, viral, or genetic factors may be involved.
TAR DNA-binding protein 43 (TDP-43), is a critical component of the non-homologous end joining (NHEJ) enzymatic pathway that repairs DNA double-strand breaks in pluripotent stem cell-derived motor neurons.[10] TDP-43 is rapidly recruited to double-strand breaks where it acts as a scaffold for the recruitment of the XRCC4-DNA ligase protein complex that then acts to repair double-strand breaks. About 95% of ALS patients have abnormalities in the nucleus-cytoplasmic localization in spinal motor neurons of TDP43. In TDP-43 depleted human neural stem cell-derived motor neurons, as well as in sporadic ALS patients' spinal cord specimens there is significant double-strand break accumulation and reduced levels of NHEJ.[10]
In adults, men are more commonly affected than women.
Differential diagnosis can be challenging due to the number of overlapping symptoms, shared between several motor neuron diseases.[11] Frequently, the diagnosis is based on clinical findings (i.e. LMN vs. UMN signs and symptoms, patterns of weakness), family history of MND, and a variation of tests, many of which are used to rule out disease mimics, which can manifest with identical symptoms.[12]
Motor neuron disease describes a collection of clinical disorders, characterized by progressive muscle weakness and the degeneration of the motor neuron on electrophysiological testing. The term "motor neuron disease" has varying meanings in different countries. Similarly, the literature inconsistently classifies which degenerative motor neuron disorders can be included under the umbrella term "motor neuron disease". The four main types of MND are marked (*) in the table below.[13]
All types of MND can be differentiated by two defining characteristics:
Sporadic or acquired MNDs occur in patients with no family history of degenerative motor neuron disease. Inherited or genetic MNDs adhere to one of the following inheritance patterns: autosomal dominant, autosomal recessive, or X-linked. Some disorders, like ALS, can occur sporadically (85%) or can have a genetic cause (15%) with the same clinical symptoms and progression of disease.
UMNs are motor neurons that project from the cortex down to the brainstem or spinal cord.[14] LMNs originate in the anterior horns of the spinal cord and synapse on peripheral muscles. Both motor neurons are necessary for the strong contraction of a muscle, but damage to an UMN can be distinguished from damage to a LMN by physical exam.[15]
| Type | UMN degeneration | LMN degeneration | |
|---|---|---|---|
| Sporadic MNDs | |||
| Sporadic amyotrophic lateral sclerosis (ALS)* | Yes | Yes | |
| Primary lateral sclerosis (PLS)* | Yes | No | |
| Progressive muscular atrophy (PMA)* | No | Yes | |
| Progressive bulbar palsy (PBP)* | Yes | Yes, bulbar region | |
| Pseudobulbar palsy | Yes, bulbar region | No | |
| Monomelic amyotrophy (MMA) | No | Yes | |
| Inherited MNDs | |||
| Familial amyotrophic lateral sclerosis (ALS)* | Yes | Yes | |
There are no known curative treatments for the majority of motor neuron disorders. Please refer to the articles on individual disorders for more details.[18]
The table below lists life expectancy for patients who are diagnosed with MND.
| Type | Median survival time from start of symptoms | |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | 2–5 years[19] | |
| Primary lateral sclerosis (PLS) | 8–10 years | |
| Progressive muscular atrophy (PMA) | 2–4 years | |
| Progressive bulbar palsy (PBP) | 6 months – 3 years | |
| Pseudobulbar palsy | No change in survival |
In the United States and Canada, the term motor neuron disease usually refers to the group of disorders while amyotrophic lateral sclerosis is frequently called Lou Gehrig's disease.[1] [20] [21] In the United Kingdom and Australia, the term motor neuron(e) disease is used for amyotrophic lateral sclerosis,[2] [3] although is not uncommon to refer to the entire group.[22] [23]
While MND refers to a specific subset of similar diseases, there are numerous other diseases of motor neurons that are referred to collectively as "motor neuron disorders", for instance the diseases belonging to the spinal muscular atrophies group.[24] However, they are not classified as "motor neuron diseases" by the 11th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD-11),[25] which is the definition followed in this article.