Monocytopenia Explained

Monocytopenia
Field:	hematology

Monocytopenia is a form of leukopenia associated with a deficiency of monocytes.

It has been proposed as a measure during chemotherapy to predict neutropenia,^[1] though some research indicates that it is less effective than lymphopenia.^[2]

Causes

The causes of monocytopenia include: acute infections, stress, treatment with glucocorticoids, aplastic anemia, hairy cell leukemia, acute myeloid leukemia, treatment with myelotoxic drugs, intestinal resection, and genetic syndromes, as for example MonoMAC syndrome.^[3]

Diagnosis

- Blood Test (CBC) (Normal range of Monocytes: 1-10%) (Normal range in males: 0.2-0.8 x 10 3 /microliter)

- Blood test checking for monocytopenia (Abnormal ranges: <1%) (Abnormal range in males: <0.2 x 10 3 /microliter)

Treatment

Monocytopenia may be treated with hematopoietic stem cell transplantation. ^[4]

Notes and References

1. Kondo M, Oshita F, Kato Y, Yamada K, Nomura I, Noda K . Early monocytopenia after chemotherapy as a risk factor for neutropenia . . 22 . 1 . 103–5 . 1999 . 10025393 . 10.1097/00000421-199902000-00025.
2. Oguz A, Karadeniz C, Ckitak EC, Cil V . 35305292 . Which one is a risk factor for chemotherapy-induced febrile neutropenia in childhood solid tumors: early lymphopenia or monocytopenia? . . 23 . 2 . 143–51 . 2006 . 16651243 . 10.1080/08880010500457673 .
3. Book: Harrison's principles of internal medicine. . limited. 2005 . McGraw-Hill . New York . 978-0-07-140235-4 . 356 .
4. Web site: Monocytopenia - Hematology and Oncology . 2023-08-23 . Merck Manuals Professional Edition . en-US.