Monobenzyl phthalate explained

Monobenzyl phthalate (MBzP) also known as 1,2-Benzenedicarboxylic acid, 1-(phenylmethyl) ester is an organic compound with the condensed structural formula C₆H₅CH₂OOCC₆H₄COOH. It is the major metabolite of butyl benzyl phthalate(BBP), a common plasticizer.^[1] BBP can also be metabolized into monobutyl phthalate (MBP).^{[2] [3]} Like many phthalates, BBP has attracted attention as a potential endocrine disruptor.^{[4] [5] [6]}

Notes and References

1. Chatterjee . Subhankar . Karlovsky . Petr . Removal of the endocrine disrupter butyl benzyl phthalate from the environment . Applied Microbiology and Biotechnology . June 2010 . 87 . 1 . 61–73 . 10.1007/s00253-010-2570-y. 20396882 . 2872021 .
2. Book: Chemical Behavior of Phthalates Under Abiotic Conditions in Landfills. Reviews of Environmental Contamination and Toxicology. 224. Huang. Jingyu. Nkrumah. Philip N.. Li. Yi. Appiah-Sefah. Gloria. 2013. Springer Science+Business Media. New York, NY. 9781461458814. 39–52. 10.1007/978-1-4614-5882-1_2. 23232918.
3. Saillenfait AM, Sabaté JP, Gallissot F . Comparative embryotoxicities of butyl benzyl phthalate, mono-n-butyl phthalate and mono-benzyl phthalate in mice and rats: in vivo and in vitro observations . Reproductive Toxicology . 17 . 5 . 575–83 . 2002 . 14555196 . 10.1016/s0890-6238(03)00102-3 .
4. Du . Zuo . Cao . Yun-Feng . Li . Sai-Nan . Hu . Cui-Min . Fu . Zhi-Wei . Huang . Chun-Ting . Sun . Xiao-Yu . Liu . Yong-Zhe . Yang . Kun . Fang . Zhong-Ze . Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters . Chemosphere . April 2018 . 197 . 7–13 . 10.1016/j.chemosphere.2018.01.010. 29328989 . 2018Chmsp.197....7D .
5. Ema M, Harazono A, Miyawaki E, Ogawa Y . Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats . Toxicology Letters . 86 . 1 . 19–25 . July 1996 . 8685916 . 10.1016/0378-4274(96)03665-x .
6. Ema M, Harazono A, Miyawaki E, Ogawa Y . Characterization of developmental toxicity of mono-n-benzyl phthalate in rats . Reproductive Toxicology . 10 . 5 . 365–72 . 1995 . 8888408 . 10.1016/0890-6238(96)00082-2 .