Monalazone Explained

Monalazone, used as monalazone disodium (; the disodium salt) and sold under the brand names Naclobenz-Natrium, Spergisin, and Speton, is a vaginal disinfectant or antiseptic and spermicidal contraceptive.^{[1] [2] [3] [4]} It is a sulfonylbenzoic acid derivative and is closely related structurally to halazone. The compound was synthesized in 1937. A vaginal tablet combination of 0.125 mg estradiol benzoate and 10 mg monalazone was previously marketed under the brand name Malun 25.^[5]

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 834–.
2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 31 October 1999. Springer Science & Business Media. 978-0-7514-0499-9. 185–.
3. Book: Martindale W, ((Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences)) . The Extra Pharmacopoeia. 1993. Pharmaceutical Press. 978-0-85369-300-0. 800. Monalazone disodium is an antiseptic closely related structurally to halazone (see p.796) and is used as a vaginal disinfectant and spermicide. Proprietary Names Malun N. Sperlisin. Multi-ingredient preparations. Malun..
4. Book: RÖMPP Lexikon Chemie . 10. Auflage, 1996-1999 . Band 4: M - Pk. 16 July 2014. Thieme. 978-3-13-200031-5. 2000–2001.
5. Book: Leidenberger FA . Klinische Endokrinologie für Frauenärzte. 17 April 2013. Springer-Verlag. 978-3-662-08110-5. 527–.