Molybdopterin molybdotransferase explained

Molybdopterin molybdotransferase
Ec Number:	2.10.1.1

Molybdopterin molybdotransferase (MoeA, Cnx1) is an enzyme with systematic name adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

\rightleftharpoons molybdenum cofactor + AMP

Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin.

Notes and References

1. Nichols JD, Rajagopalan KV . In vitro molybdenum ligation to molybdopterin using purified components . The Journal of Biological Chemistry . 280 . 9 . 7817–22 . March 2005 . 15632135 . 10.1074/jbc.M413783200 . free .
2. Nichols JD, Xiang S, Schindelin H, Rajagopalan KV . Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft . Biochemistry . 46 . 1 . 78–86 . January 2007 . 17198377 . 1868504 . 10.1021/bi061551q .
3. Llamas A, Otte T, Multhaup G, Mendel RR, Schwarz G . The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly . The Journal of Biological Chemistry . 281 . 27 . 18343–50 . July 2006 . 16636046 . 10.1074/jbc.M601415200 . free .