Molybdopterin adenylyltransferase explained

Molybdopterin adenylyltransferase
Ec Number:2.7.7.75

Molybdopterin adenylyltransferase (MogA, Cnx1) is an enzyme with systematic name ATP:molybdopterin adenylyltransferase.[1] [2] [3] This enzyme catalyses the following chemical reaction

\rightleftharpoons

diphosphate + adenylyl-molybdopterin

This enzyme catalyses the activation of molybdopterin for molybdenum insertion.

Notes and References

  1. Nichols JD, Rajagopalan KV . In vitro molybdenum ligation to molybdopterin using purified components . The Journal of Biological Chemistry . 280 . 9 . 7817–22 . March 2005 . 15632135 . 10.1074/jbc.M413783200 . free .
  2. Kuper J, Palmer T, Mendel RR, Schwarz G . Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization . Proceedings of the National Academy of Sciences of the United States of America . 97 . 12 . 6475–80 . June 2000 . 10823911 . 18627 . 10.1073/pnas.110568497 . free . 2000PNAS...97.6475K .
  3. Llamas A, Mendel RR, Schwarz G . Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion . The Journal of Biological Chemistry . 279 . 53 . 55241–6 . December 2004 . 15504727 . 10.1074/jbc.M409862200 . free .

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