Molybdenum cofactor guanylyltransferase explained

Molybdenum cofactor guanylyltransferase
Ec Number:2.7.7.77

Molybdenum cofactor guanylyltransferase (MobA, MoCo guanylyltransferase) is an enzyme with systematic name GTP:molybdenum cofactor guanylyltransferase.[1] [2] [3] This enzyme catalyses the following chemical reaction:

\rightleftharpoons

diphosphate + guanylyl molybdenum cofactor

Catalyses the guanylation of the molybdenum cofactor.

Notes and References

  1. Lake MW, Temple CA, Rajagopalan KV, Schindelin H . The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis . The Journal of Biological Chemistry . 275 . 51 . 40211–7 . December 2000 . 10978347 . 10.1074/jbc.m007406200 . free .
  2. Temple CA, Rajagopalan KV . Mechanism of assembly of the Bis(Molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase . The Journal of Biological Chemistry . 275 . 51 . 40202–10 . December 2000 . 10978348 . 10.1074/jbc.m007407200 . free .
  3. Guse A, Stevenson CE, Kuper J, Buchanan G, Schwarz G, Giordano G, Magalon A, Mendel RR, Lawson DM, Palmer T . Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA . The Journal of Biological Chemistry . 278 . 28 . 25302–7 . July 2003 . 12719427 . 10.1074/jbc.m302639200 . free .

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