Mitozolomide Explained

Mitozolomide (INN) is an antineoplastic. It is an imidazotetrazine derivative.

Development of mitozolomide was discontinued during Phase II clinical trials after it was found to cause severe and unpredictable bone marrow suppression.^[1] Temozolomide, which has been in clinical use since 1999, is a less toxic analogue of mitozolomide.^[2]

References

1. Fairbairn LJ, Chinnasamy N, Lashford LS, Chinnasamy D, Rafferty JA . Enhancing hemopoietic drug resistance: a rationale for reconsidering the clinical use of mitozolomide . Cancer Gene Ther . 7 . 2 . 233–9 . February 2000 . 10770631 . 10.1038/sj.cgt.7700120. 2597751 . free .
2. Newlands ES, Blackledge GR, Slack JA, etal . Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856) . Br J Cancer . 65 . 2 . 287–91 . February 1992 . 1739631 . 1977719 . 10.1038/bjc.1992.57.