Mitochondrial intermediate peptidase explained

Mitochondrial intermediate peptidase
Ec Number:	3.4.24.59
Cas Number:	136447-30-8

Mitochondrial intermediate peptidase (mitochondrial intermediate precursor-processing proteinase, MIP) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion

This enzyme is a homologue of thimet oligopeptidase.

Notes and References

1. Isaya G, Kalousek F, Rosenberg LE . Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase . The Journal of Biological Chemistry . 267 . 11 . 7904–10 . April 1992 . 10.1016/S0021-9258(18)42598-7 . 1560019 . free .
2. Isaya G, Kalousek F, Rosenberg LE . Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue . Proceedings of the National Academy of Sciences of the United States of America . 89 . 17 . 8317–21 . September 1992 . 1518864 . 49909 . 10.1073/pnas.89.17.8317 . free .