Mir-130 microRNA precursor family explained
| mir-130 microRNA precursor family |
| Symbol: | mir-130 |
| Rfam: | RF00258 |
| Mirbase: | MI0000448 |
| Mirbase Family: | MIPF0000034 |
| Rna Type: | Gene
- miRNA
|
| Tax Domain: | Eukaryota |
In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408),[1] and in human (MI0000448, MI0000748).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4]
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Notes and References
- Lagos-Quintana . M . Rauhut R . Yalcin A . Meyer J . Lendeckel W . Tuschl T . 2002 . Identification of tissue-specific microRNAs from mouse . Curr Biol . 12 . 735 - 739 . 12007417 . 10.1016/S0960-9822(02)00809-6 . 9. 11858/00-001M-0000-0010-94EF-7 . 7901788 . free .
- Houbaviy . HB . Murray MF . Sharp PA . 2003 . Embryonic stem cell-specific MicroRNAs . Dev Cell . 5 . 351 - 358 . 12919684 . 10.1016/S1534-5807(03)00227-2 . 2. free .
- Kutay H, Bai S, Datta J, etal . Downregulation of miR-122 in the rodent and human hepatocellular carcinomas . J. Cell. Biochem. . 99 . 3 . 671–8 . 2006 . 16924677 . 10.1002/jcb.20982 . 3033198.
- Escobar G, Moi D, Ranghetti A, etal . Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression. . Sci. Transl. Med. . 6 . 217 . Jan 2014 . 24382895 . 217 . 10.1126/scitranslmed.3006353. 8430299 .
