Mir-101 microRNA precursor family explained
| mir-101 microRNA precursor family |
| Symbol: | mir-101 |
| Rfam: | RF00253 |
| Mirbase: | MI0000103 |
| Mirbase Family: | MIPF0000046 |
| Rna Type: | Gene
- miRNA
|
| Tax Domain: | Eukaryota |
miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739)[1] and mouse (MI0000148).[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.
Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]
Further reading
- He XP, Shao Y, Li XL, Xu W, Chen GS, Sun HH, Xu HC, Xu X, Tang D, Zheng XF, Xue YP, Huang GC, Sun WH . Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth . The FEBS Journal . 279 . 22 . 4201–12 . November 2012 . 23013439 . 10.1111/febs.12013 . 205132426 . free .
External links
Notes and References
- Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G . miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs . Genes & Development . 16 . 6 . 720–8 . March 2002 . 11914277 . 155365 . 10.1101/gad.974702 .
- Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse . Current Biology . 12 . 9 . 735–9 . April 2002 . 12007417 . 10.1016/S0960-9822(02)00809-6 . 11858/00-001M-0000-0010-94EF-7 . 7901788 . free .
- Lánczky A, Nagy Á, Bottai G, Munkácsy G, Szabó A, Santarpia L, Győrffy B . miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients . Breast Cancer Research and Treatment . 160 . 3 . 439–446 . December 2016 . 27744485 . 10.1007/s10549-016-4013-7 . 11165696 .
