Osteoglycin Explained

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.^[1]

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan^[2] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.^{[3] [4]}

Further reading

• Kukita A . Osteoinductive factor inhibits formation of human osteoclast-like cells . Proc. Natl. Acad. Sci. U.S.A. . 87 . 8 . 3023–6 . 1990 . 2326263 . 10.1073/pnas.87.8.3023 . 53826 . vanc. Bonewald L . Rosen D . 3 . Seyedin . S . Mundy . GR . Roodman . GD . 1990PNAS...87.3023K . free .
• Madisen L . Molecular cloning of a novel bone-forming compound: osteoinductive factor . DNA Cell Biol. . 9 . 5 . 303–9 . 1990 . 2372374 . 10.1089/dna.1990.9.303 . vanc. Neubauer M . Plowman G . 3 . Rosen . David . Segarini . Patricia . Dasch . James . Thompson . Andrea . Ziman . J. . Bentz . Hanne .
• Tasheva ES . The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon . J. Biol. Chem. . 274 . 26 . 18693–701 . 1999 . 10373482 . 10.1074/jbc.274.26.18693 . vanc. Funderburgh ML . McReynolds J . 3 . Funderburgh . JL . Conrad . GW . free.
• Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH . Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin . Proteins . 38 . 2 . 210–25 . 2000 . 10656267 . 10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1 . 39643243 .
• Pellegata NS . Mutations in KERA, encoding keratocan, cause cornea plana . Nat. Genet. . 25 . 1 . 91–5 . 2000 . 10802664 . 10.1038/75664 . vanc. Dieguez-Lucena JL . Joensuu T . 3 . Joensuu . Tarja . Lau . Stephanie . Montgomery . Kate T. . Krahe . Ralf . Kivelä . Tero . Kucherlapati . Raju . 8837115 .
• Tasheva ES, Pettenati M, Von Kap-Her C, Conrad GW . Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization . Cytogenet. Cell Genet. . 88 . 3–4 . 326–7 . 2000 . 10828622 . 10.1159/000015521 . 39568354 .
• Hu RM . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . vanc. Han ZG . Song HD . 3 . Peng . YD . Huang . QH . Ren . SX . Gu . YJ . Huang . CH . Li . YB . 2000PNAS...97.9543H . free .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Simpson JC . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . vanc. Wellenreuther R . Poustka A . 3 . Pepperkok . R . Wiemann . S .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Tasheva ES, Conrad GW . The UV responsive elements in the human mimecan promoter: a functional characterization . Mol. Vis. . 9 . 1–9 . 2003 . 12533723 .
• Luijendijk MW . Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs . Genomics . 82 . 4 . 480–90 . 2004 . 13679028 . 10.1016/S0888-7543(03)00150-2 . vanc. van de Pol TJ . van Duijnhoven G . 3 . Den Hollander . A.I. . Ten Caat . J. . Van Limpt . V. . Brunner . H.G. . Kremer . H. . Cremers . F.P.M. .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . vanc. Oliver K . Hunt AR . 3 . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wiemann S . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Hu SM . The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors . J. Clin. Endocrinol. Metab. . 90 . 12 . 6657–64 . 2006 . 16189248 . 10.1210/jc.2005-0322 . vanc. Li F . Yu HM . 3 . Li . RY . Ma . QY . Ye . TJ . Lu . ZY . Chen . JL . Song . HD . free .
• Otsuki T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . vanc. Ota T . Nishikawa T . 3 . Hayashi . K . Suzuki . Y . Yamamoto . J . Wakamatsu . A . Kimura . K . Sakamoto . K . free .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .

Notes and References

1. Web site: Entrez Gene: OGN osteoglycin.
2. Funderburgh JL, Corpuz LM, Roth MR, Funderburgh ML, Tasheva ES, Conrad GW. Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin. . J Biol Chem . 1997 . 272 . 44 . 28089–95 . 9346963 . 10.1074/jbc.272.44.28089 . free .
3. Web site: Big hearts 'have genetic problem' . 2008-06-06 . Health . BBC News . 2008-06-07.
4. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA . Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass . Nat. Genet. . 40 . 5 . 546–52 . May 2008 . 18443592 . 10.1038/ng.134 . 2742198 .