Midaflur Explained

Midaflur (INN; EXP 338) is an extremely stable 3-imidazoline derivative with central skeletal muscle relaxant and sedative properties in humans[1] and other species of mammals, exhibiting consistently high oral bioavailability and a long duration of action. While its pharmacodynamics remain poorly understood, midaflur resembles meprobamate and pentobarbital in terms of observed effects while being considerably more potent.[2]

See also

Notes and References

  1. Levine IM, Jossmann PB, Friend DG, DeAngelis V . Effect of 5-imino-2,2,4,4-tetrakis (trifluoromethyl) imidazolidine (EXP 338) on spasticity: A quantitative evaluation . Clinical Pharmacology and Therapeutics . 9 . 4 . 448–55 . 1967 . 4871898 . 10.1002/cpt196894448 . 39263140 .
  2. Clark R, Lynes TE, Price WA, Smith DH, Woodward JK, Marvel JP, Vernier VG . The pharmacology and toxicology of midaflur . Toxicology and Applied Pharmacology . 18 . 4 . 917–43 . April 1971 . 5570243 . 10.1016/0041-008x(71)90239-0 .

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