MAP1B explained

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^{[1] [2]}

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[3] and RASSF1.^[4]

Further reading

• Hammarback JA, Obar RA, Hughes SM, Vallee RB . MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain . Neuron . 7 . 1 . 129–39 . 1991 . 1712602 . 10.1016/0896-6273(91)90081-A . 34690111 .
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB . MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS . J. Neurosci. . 9 . 5 . 1712–30 . 1989 . 2470876 . 10.1523/JNEUROSCI.09-05-01712.1989. 6569839 . free .
• Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J . Role of phosphorylated MAPlB in neuritogenesis . Cell Biol. Int. . 18 . 5 . 309–14 . 1994 . 7519512 . 10.1006/cbir.1994.1079 . 85789590 .
• Lien LL, Feener CA, Fischbach N, Kunkel LM . Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15 . Genomics . 22 . 2 . 273–80 . 1994 . 7806212 . 10.1006/geno.1994.1384 .
• Ohyu J, Takashima S . Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions . Brain Dev. . 20 . 1 . 22–6 . 1998 . 9533556 . 10.1016/S0387-7604(97)00088-0 . 20265712 .
• Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC . Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium . J. Cell Sci. . 111 (Pt 10) . 10 . 1351–61 . 1998 . 10.1242/jcs.111.10.1351 . 9570753 .
• Tögel M, Wiche G, Propst F . Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain . J. Cell Biol. . 143 . 3 . 695–707 . 1998 . 9813091 . 2148156 . 10.1083/jcb.143.3.695 .
• Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ . The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses . Nature . 397 . 6714 . 66–9 . 1999 . 9892354 . 10.1038/16258 . 1999Natur.397...66H . 4421437 .
• Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP . Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments . J. Biol. Chem. . 275 . 28 . 21500–7 . 2000 . 10764738 . 10.1074/jbc.M000099200 . free .
• Tanner SL, Franzen R, Jaffe H, Quarles RH . Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein . J. Neurochem. . 75 . 2 . 553–62 . 2000 . 10899930 . 10.1046/j.1471-4159.2000.0750553.x . 33325478 . free .
• Mei X, Sweatt AJ, Hammarback JA . Regulation of microtubule-associated protein 1B (MAP1B) subunit composition . J. Neurosci. Res. . 62 . 1 . 56–64 . 2000 . 11002287 . 10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-# . 196600490 .
• Billups D, Hanley JG, Orme M, Attwell D, Moss SJ . GABAC receptor sensitivity is modulated by interaction with MAP1B . J. Neurosci. . 20 . 23 . 8643–50 . 2000 . 11102469 . 10.1523/JNEUROSCI.20-23-08643.2000. 6773065 . free .
• Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH . Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein . J. Cell Biol. . 155 . 6 . 893–8 . 2001 . 11733546 . 2150906 . 10.1083/jcb.200108137 .
• Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y . Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin . J. Cell Biol. . 158 . 3 . 427–33 . 2002 . 12147674 . 2173828 . 10.1083/jcb.200202055 .
• Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA . Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region . Biomol. Eng. . 20 . 3 . 91–6 . 2003 . 12684070 . 10.1016/S1389-0344(03)00003-0 .
• Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M . JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins . Dev. Cell . 4 . 4 . 521–33 . 2003 . 12689591 . 10.1016/S1534-5807(03)00094-7 . free .
• Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY . Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis . J. Biol. Chem. . 278 . 36 . 34691–9 . 2003 . 12807913 . 10.1074/jbc.M302785200 . free .

Notes and References

1. Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM . Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13 . Proc. Natl. Acad. Sci. U.S.A. . 88 . 17 . 7873–6 . Oct 1991 . 1881920 . 52406 . 10.1073/pnas.88.17.7873 . 1991PNAS...88.7873L . free .
2. Web site: Entrez Gene: MAP1B microtubule-associated protein 1B.
3. Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY. Huda Zoghbi . Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis . J. Biol. Chem. . 278 . 36 . 34691–9 . Sep 2003 . 12807913 . 10.1074/jbc.M302785200 . free .
4. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F . RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics . Cancer Res. . 64 . 12 . 4112–6 . Jun 2004 . 15205320 . 10.1158/0008-5472.CAN-04-0267 . free .