Microbial collagenase explained

Microbial collagenase
Ec Number:3.4.24.3
Cas Number:2593923

Microbial collagenase (Clostridium histolyticum collagenase, clostridiopeptidase A, collagenase A, collagenase I, Achromobacter iophagus collagenase, collagenase, aspergillopeptidase C, nucleolysin, azocollase, metallocollagenase, soycollagestin, Clostridium histolyticum proteinase A, clostridiopeptidase II, MMP-8, clostridiopeptidase I, collagen peptidase, collagen protease, collagenase MMP-1, metalloproteinase-1, kollaza, matrix metalloproteinase-1, matrix metalloproteinase-8, matirx metalloproteinase-18, interstitial collagenase) is an enzyme.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] This enzyme catalyses the following chemical reaction

Digestion of native collagen in the triple helical region at -Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'

Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum.

See also

Notes and References

  1. The isolation of collagenase and its enzymological and physico-chemical properties . Hanada, K. . Mizutani, T. . Yamagishi, M. . Tsuji, H. . Misaki, T. . Sawada, J. . Agric. Biol. Chem. . 1973 . 37 . 8 . 1771–1781 . 10.1271/bbb1961.37.1771.
  2. Merkel JR, Dreisbach JH . Purification and characterization of a marine bacterial collagenase . Biochemistry . 17 . 14 . 2857–63 . July 1978 . 210785 . 10.1021/bi00607a025 .
  3. Heindl MC, Fermandjian S, Keil B . Circular dichroism comparative studies of two bacterial collagenases and thermolysin . Biochimica et Biophysica Acta (BBA) - Protein Structure . 624 . 1 . 51–9 . July 1980 . 6250633 . 10.1016/0005-2795(80)90224-x .
  4. Labadie J, Montel MC . [Purification and study of some properties of a collagenase produced by Empedobacter collagenolyticum] . Biochimie . 64 . 1 . 49–53 . January 1982 . 6279175 . 10.1016/s0300-9084(82)80609-3 .
  5. Bond MD, Van Wart HE . Characterization of the individual collagenases from Clostridium histolyticum . Biochemistry . 23 . 13 . 3085–91 . June 1984 . 6087888 . 10.1021/bi00308a036 .
  6. Bond MD, Van Wart HE . Relationship between the individual collagenases of Clostridium histolyticum: evidence for evolution by gene duplication . Biochemistry . 23 . 13 . 3092–9 . June 1984 . 6087889 . 10.1021/bi00308a037 .
  7. Van Wart HE, Steinbrink DR . Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum . Biochemistry . 24 . 23 . 6520–6 . November 1985 . 3002445 . 10.1021/bi00344a032 .
  8. Purification and characterization of two high-molecular-mass forms of Achromobacter collagenase . Tong, N.T. . Tsugita, A. . Keil-Dlouha, V. . Biochim. Biophys. Acta . 1986 . 874 . 3 . 296–304 . 10.1016/0167-4838(86)90028-2.
  9. Endo A, Murakawa S, Shimizu H, Shiraishi Y . Purification and properties of collagenase from a Streptomyces species . Journal of Biochemistry . 102 . 1 . 163–70 . July 1987 . 2822678 . 10.1093/oxfordjournals.jbchem.a122028 .
  10. Makinen KK, Makinen PL . Purification and properties of an extracellular collagenolytic protease produced by the human oral bacterium Bacillus cereus (strain Soc 67) . The Journal of Biological Chemistry . 262 . 26 . 12488–95 . September 1987 . 10.1016/S0021-9258(18)45232-5 . 3040751 . free .

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