MiR-150 explained
| miR-150 |
| Symbol: | miR-150 |
| Altsymbols: | MIR150 |
| Rfam: | RF00767 |
| Mirbase: | MI0000479 |
| Mirbase Family: | MIPF0000197 |
| Rna Type: | miRNA |
| Tax Domain: | Mammalia |
| Go: | 0035195 |
| So: | 0001244 |
| Entrezgene: | 406942 |
| Hgncid: | 31537 |
| Omim: | 610566 |
| Refseq: | NR_029703 |
| Chromosome: | 19 |
| Arm: | q |
| Band: | 13.33 |
miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.[3] [4] It is also thought to control B and T cell differentiation, alongside miR-155.[5] [6]
Role in cancer
miR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.[7]
Applications
miR-150 levels in blood plasma can be indicative of early sepsis; it could have a future use therapeutically in treating the condition.[8] In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.[9]
Further reading
- Tsitsiou E, Lindsay MA . microRNAs and the immune response . Current Opinion in Pharmacology . 9 . 4 . 514–20 . Aug 2009 . 19525145 . 2742742 . 10.1016/j.coph.2009.05.003 .
- Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J . Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia . Cancer Cell . 22 . 4 . 524–35 . Oct 2012 . 23079661 . 10.1016/j.ccr.2012.08.028 . 3480215 .
Notes and References
- Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . Dec 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . 14574186 . free .
- Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R . Human RISC couples microRNA biogenesis and posttranscriptional gene silencing . Cell . 123 . 4 . 631–40 . Nov 2005 . 16271387 . 10.1016/j.cell.2005.10.022 . 16973870 . free .
- Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR . MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors . Developmental Cell . 14 . 6 . 843–53 . Jun 2008 . 18539114 . 2688789 . 10.1016/j.devcel.2008.03.012 .
- Edelstein LC, Bray PF . MicroRNAs in platelet production and activation . Blood . 117 . 20 . 5289–96 . May 2011 . 21364189 . 3109704 . 10.1182/blood-2011-01-292011 .
- Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J . The role of microRNAs in normal and malignant hematopoiesis . European Journal of Haematology . 84 . 1 . 1–16 . Jan 2010 . 19744129 . 10.1111/j.1600-0609.2009.01348.x . 46395419 . free .
- Garzon R, Croce CM . MicroRNAs in normal and malignant hematopoiesis . Current Opinion in Hematology . 15 . 4 . 352–8 . Jul 2008 . 18536574 . 10.1097/MOH.0b013e328303e15d . 12931709 .
- Lulla RR, Costa FF, Bischof JM, Chou PM, Bonaldo MF, Vanin EF, Soares MB . Identification of Differentially Expressed MicroRNAs in Osteosarcoma . Sarcoma . 2011 . 732690 . 2011 . 21789031 . 3140035 . 10.1155/2011/732690 . free .
- Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, Ferracin M, Nicoloso MS, Barbarotto E, Popa M, Stanciulea O, Fernandez MH, Tulbure D, Bueso-Ramos CE, Negrini M, Calin GA . MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis . PLOS ONE . 4 . 10 . e7405 . 2009-10-12 . 19823581 . 2756627 . 10.1371/journal.pone.0007405 . 2009PLoSO...4.7405V . Gold . Jeffrey A . free .
- Magrelli A, Azzalin G, Salvatore M, Viganotti M, Tosto F, Colombo T, Devito R, Di Masi A, Antoccia A, Lorenzetti S, Maranghi F, Mantovani A, Tanzarella C, Macino G, Taruscio D . Altered microRNA Expression Patterns in Hepatoblastoma Patients . Translational Oncology . 2 . 3 . 157–63 . Aug 2009 . 19701500 . 2730135 . 10.1593/tlo.09124.
