MIR146A explained
MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.[1]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[2]
Further reading
- Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T . Identification of tissue-specific microRNAs from mouse . Current Biology . 12 . 9 . 735–9 . April 2002 . 12007417 . 10.1016/S0960-9822(02)00809-6 . free . 2002CBio...12..735L .
- Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR . Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells . Proceedings of the National Academy of Sciences of the United States of America . 102 . 15 . 5570–5 . April 2005 . 15800047 . 556237 . 10.1073/pnas.0408192102 . 2005PNAS..102.5570C . free .
- He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la Chapelle A . The role of microRNA genes in papillary thyroid carcinoma . Proceedings of the National Academy of Sciences of the United States of America . 102 . 52 . 19075–80 . December 2005 . 16365291 . 1323209 . 10.1073/pnas.0509603102 . 2005PNAS..10219075H . free .
- Taganov KD, Boldin MP, Chang KJ, Baltimore D . NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses . Proceedings of the National Academy of Sciences of the United States of America . 103 . 33 . 12481–6 . August 2006 . 16885212 . 1567904 . 10.1073/pnas.0605298103 . 2006PNAS..10312481T . free .
- Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A . MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? . PLOS ONE . 2 . 7 . e610 . July 2007 . 17622355 . 1905940 . 10.1371/journal.pone.0000610 . 2007PLoSO...2..610S . Zimmer . Jacques . free .
- Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK . Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways . Journal of Virology . 82 . 4 . 1946–58 . February 2008 . 18057241 . 2258704 . 10.1128/JVI.02136-07 .
- Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D . Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis . Arthritis and Rheumatism . 58 . 4 . 1001–9 . April 2008 . 18383392 . 10.1002/art.23386 .
- Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA . Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells . Journal of Immunology . 180 . 8 . 5689–98 . April 2008 . 18390754 . 2639646 . 10.4049/jimmunol.180.8.5689 .
- Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A . Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma . Proceedings of the National Academy of Sciences of the United States of America . 105 . 20 . 7269–74 . May 2008 . 18474871 . 2438239 . 10.1073/pnas.0802682105 . 2008PNAS..105.7269J . free .
- Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C . A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis . Nature Cell Biology . 10 . 7 . 788–801 . July 2008 . 18568019 . 10.1038/ncb1741 . 30191805 .
Notes and References
- Web site: Entrez Gene: MicroRNA 146a. 2012-01-27 .
- Web site: Entrez Gene: MicroRNA 146a. 2012-01-27 .