Mevaldate reductase (NADPH) explained

mevaldate reductase (NADPH)
Ec Number:	1.1.1.33
Cas Number:	9028-34-6
Go Code:	0019726

In enzymology, a mevaldate reductase (NADPH) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NADP⁺

\rightleftharpoons mevaldate + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-mevalonate and NADP⁺, whereas its 3 products are mevaldate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP⁺ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).

References

• Book: Schomburg D, Stephan D . Enzyme Handbook 9 . Mevaldate reductase (NADPH) . 9 . 1995 . 189–191 . Springer . Berlin, Heidelberg . 10.1007/978-3-642-85200-8_33 . 978-3-642-85200-8 .
• Book: Wolstenholme GE, O'Connor M . CIBA Symposium on the Biosynthesis of Terpenes and Sterols . London . 1959 . 62–74 .
• Book: Jakoby WB . Enzymatic Basis of Detoxication . 1 . Academic Press . New York . 1980 . 249–260 .