Mevaldate reductase explained

mevaldate reductase (NAD^+)
Ec Number:	1.1.1.32
Cas Number:	9028-33-5
Go Code:	0019727

In enzymology, a mevaldate reductase is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NAD⁺

\rightleftharpoons mevaldate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-mevalonate and NAD⁺, whereas its 3 products are mevaldate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD⁺ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.

In 2022, this entry was deleted from the Enzyme Classification, and is now included in with the entry for Alcohol dehydrogenase.^[1]

References

• Schlesinger MJ, Coon MJ . 1961 . Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver . J. Biol. Chem. . 236 . 2421 - 2424 .

Notes and References

1. Web site: EC 1.1.1.32 . ExplorEnz – the Enzyme Databas . International Union of Biochemistry and Molecular Biology (IUBMB) . Deleted entry: mevaldate reductase, now included with EC 1.1.1.1, alcohol dehydrogenase. .