N-Methylpiperazine Explained

N-Methylpiperazine is a heterocyclic organic compound.

Uses

N-Methylpiperazine is a common building block used in organic synthesis.^[1] For example, N-methylpiperazine is used in the manufacture of various pharmaceutical drugs including cyclizine,^[2] meclizine, and sildenafil.

The lithium salt, lithium N-methylpiperazide, is used as a reagent in organic synthesis for protection of aryl aldehydes.^[3]

Synthesis

Industrially, N-methylpiperazine is produced by reacting diethanolamine and methylamine at 250 bar and 200 °C.^{[4] [5]}

Notes and References

1. Web site: 1-methylpiperazine . .
2. Book: Vardanyan, Ṛuben & Hruby, Victor J. . 226 . Synthesis of Essential Drugs .
3. Book: 10.1002/047084289X.rl128 . Lithium N-Methylpiperazide . . 2001 . Comins . Daniel L. . Joseph . Sajan P. . 0471936235 .
4. US. 4845218. Preparation of N-Methylpiperazine. 1989-07-04. 1987-02-14.
5. Catalytic synthesis of N-methylpiperazine from diethanolamine and methylamine by cyclodehydration reaction. Indian Journal of Chemical Technology. 1. November. 1994. 359–360.