| methylmalonate-semialdehyde dehydrogenase (acylating) | |
| Ec Number: | 1.2.1.27 |
| Cas Number: | 37205-49-5 |
| Go Code: | 0004491 |
| Width: | 270 |
In enzymology, a methylmalonate-semialdehyde dehydrogenase (acylating) is an enzyme that catalyzes the chemical reaction
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ propanoyl-CoA + HCO3- + NADH
The 4 substrates of this enzyme are 2-methyl-3-oxopropanoate, CoA, H2O, and NAD+, whereas its 3 products are propanoyl-CoA, HCO3-, and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating). Other names in common use include MSDH, and MMSA dehydrogenase. This enzyme participates in 3 metabolic pathways: inositol metabolism, valine, leucine and isoleucine degradation, and propanoate metabolism.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .