Methylglyoxal reductase (NADPH-dependent) explained

methylglyoxal reductase (NADPH-dependent)
Ec Number:	1.1.1.283
Go Code:	0043892

In enzymology, a methylglyoxal reductase (NADPH-dependent) is an enzyme that catalyzes the chemical reaction

lactaldehyde + NADP⁺

\rightleftharpoons methylglyoxal + NADPH + H⁺

Thus, the two substrates of this enzyme are lactaldehyde and NADP⁺, whereas its 3 products are methylglyoxal, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is lactaldehyde:NADP⁺ oxidoreductase. Other names in common use include lactaldehyde dehydrogenase (NADP⁺), and Gre2.

References

• Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A . 1985 . Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae . Eur. J. Biochem. . 151 . 631–636 . 3896793 . 10.1111/j.1432-1033.1985.tb09151.x . 3 . free .
• Johnston M, Chitnis PR, Kohl DH . 2003 . Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae . Yeast . 20 . 545–554 . 12722185 . 10.1002/yea.979 . 6 .