Methylecgonone reductase explained

Methylecgonone reductase
Ec Number:	1.1.1.334

Methylecgonone reductase (MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

ecgonine methyl ester + NADP⁺

\rightleftharpoons

ecgonone methyl ester + NADPH + H⁺

The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

Notes and References

Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC . Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae . Proceedings of the National Academy of Sciences of the United States of America . 109 . 26 . 10304–9 . June 2012 . 22665766 . 3387132 . 10.1073/pnas.1200473109 . 2012PNAS..10910304J . free .