S-Methylcysteine Explained

S-Methylcysteine is the amino acid with the nominal formula CH3SCH2CH(NH2)CO2H. It is the S-methylated derivative of cysteine. This amino acid occurs widely in plants, including many edible vegetables.[1]

Biosynthesis

The amino acid is not genetically coded, but it arises by post-translational methylation of cysteine. One pathway involves methyl transfer from alkylated DNA by zinc-cysteinate-containing repair enzymes.[2] [3]

Beyond its biological context, it has been examined as a chelating agent.[4]

Notes and References

  1. 10.1080/01961778208082422. Biochemistry of S-Methyl-L-Cysteine and its Principal Derivatives. Sulfur Reports. 2. 1–26. 1982. Maw. George A..
  2. 10.1111/j.1365-313X.2005.02413.x. 15941393. Analysis of Sulfur and Selenium Assimilation in Astragalus plants with Varying Capacities to Accumulate Selenium. The Plant Journal. 42. 785–797. 2005. Sors. Thomas G.. Ellis. Danielle R.. Na. Gun Nam. Lahner. Brett. Lee. Sangman. Leustek. Thomas. Pickering. Ingrid J.. Salt. David E.. 6. free.
  3. 10.1074/jbc.AW118.003235. 29743234. The ribosome: A Hot Spot for the Identification of New Types of Protein Methyltransferases. Journal of Biological Chemistry. 293. 10438–10446. 2018. Clarke. Steven G.. 27. 6036201. free.
  4. 10.1021/ic0501869. 16022542. Re(CO)3 Complexes Synthesized via an Improved Preparation of Aqueousfac-[Re(CO)3(H2O)3]+as an Aid in Assessing 99m Tc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-Bearing Amino Acids as Tridentate Ligands. Inorganic Chemistry. 44. 5437–5446. 2005. He. Haiyang. Lipowska . Malgorzata. Xu. Xiaolong. Taylor. Andrew T.. Carlone. Maria. Marzilli. Luigi G.. 15.

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