| methylated-DNA-[protein]-cysteine S-methyltransferase | |
| Ec Number: | 2.1.1.63 |
| Cas Number: | 77271-19-3 |
| Go Code: | 0003908 |
In enzymology, a methylated-DNA-[protein]-cysteine S-methyltransferase is an enzyme that catalyzes the chemical reaction
DNA (containing 6-O-methylguanine) + protein L-cysteine
\rightleftharpoons
Thus, the two substrates of this enzyme are DNA containing 6-O-methylguanine and protein L-cysteine, whereas its two products are DNA and protein S-methyl-L-cysteine. The S-methyl-L-cysteine residue irreversibly inactivates the protein, allowing only one transfer for each protein.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase.
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,, and .