Methylaspartate ammonia-lyase explained

methylaspartate ammonia-lyase
Ec Number:4.3.1.2
Cas Number:9033-26-5
Go Code:0050096

The enzyme methylaspartate ammonia-lyase (EC 4.3.1.2) catalyzes the chemical reaction

L-threo-3-methylaspartate

\rightleftharpoons

mesaconate + NH3

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming). Other names in common use include β-methylaspartase, 3-methylaspartase, and L-threo-3-methylaspartate ammonia-lyase. This enzyme participates in c5-branched dibasic acid metabolism and nitrogen metabolism. It employs one cofactor, cobamide.

Structural studies

Several structures of this enzyme have been deposited in the Protein Data Bank (linked in the infobox) which show it possesses a TIM barrel domain.

References