Methylamine dehydrogenase (amicyanin) explained

Methylamine dehydrogenase (amicyanin)
Ec Number:	1.4.9.1

Methylamine dehydrogenase (amicyanin) (amine dehydrogenase, primary-amine dehydrogenase) is an enzyme with systematic name methylamine:amicyanin oxidoreductase (deaminating).^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction:

\rightleftharpoons formaldehyde + ammonia + reduced amicyanin

This enzyme contains tryptophan tryptophylquinone (TTQ) co-factor.

Notes and References

1. de Beer R, Duine JA, Frank J, Large PJ . The prosthetic group of methylamine dehydrogenase from Pseudomonas AM1: evidence for a quinone structure . Biochimica et Biophysica Acta . 622 . 2 . 370–4 . April 1980 . 6246962 . 10.1016/0005-2795(80)90050-1 .
2. Eady RR, Large PJ . Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in growth on methylamine . The Biochemical Journal . 106 . 1 . 245–55 . January 1968 . 4388687 . 1198491 . 10.1042/bj1060245 .
3. Eady RR, Large PJ . Microbial oxidation of amines. Spectral and kinetic properties of the primary amine dehydrogenase of Pseudomonas AM1 . The Biochemical Journal . 123 . 5 . 757–71 . August 1971 . 5124384 . 1177077 . 10.1042/bj1230757 .
4. Cavalieri C, Biermann N, Vlasie MD, Einsle O, Merli A, Ferrari D, Rossi GL, Ubbink M . Structural comparison of crystal and solution states of the 138 kDa complex of methylamine dehydrogenase and amicyanin from Paracoccus versutus . Biochemistry . 47 . 25 . 6560–70 . June 2008 . 18512962 . 10.1021/bi7023749 .
5. Meschi F, Wiertz F, Klauss L, Cavalieri C, Blok A, Ludwig B, Heering HA, Merli A, Rossi GL, Ubbink M . Amicyanin transfers electrons from methylamine dehydrogenase to cytochrome c-551i via a ping-pong mechanism, not a ternary complex . Journal of the American Chemical Society . 132 . 41 . 14537–45 . October 2010 . 20873742 . 10.1021/ja105498m . 11381/2328147 . free .