Methenmadinone acetate explained

Methenmadinone acetate (MMA), also known as methylenedehydroacetoxyprogesterone (MDAP) and sold under the brand names Superlutin and Antigest, is a progestin medication which was developed in Czechoslovakia in the 1960s.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] It is the C17α acetate ester of methenmadinone.

MMA given orally shows about 13-fold the progestogenic activity of parenteral progesterone in animal bioassays.[14]

Analogues of methenmadinone acetate include methenmadinone caproate (MMC), which was studied in combination with estradiol valerate as a combined injectable contraceptive (tentative brand name Lutofollin);[15] [16] [17] chlormethenmadinone acetate (chlorsuperlutin; SCH-12600; 6-chloro-MMA),[18] which has been used in combination with mestranol in birth control pills (brand names Biogest, Sterolibrin, Antigest B)[19] [20] and in veterinary medicine (brand name Agelin);[21] bromethenmadinone acetate (bromsuperlutin; 6-bromo-MMA), which was assessed but was never marketed;[22] and melengestrol acetate (methylsuperlutin; 6-methyl-MMA), which is used in veterinary medicine.

See also

Notes and References

  1. Book: Milne GW . Ashgate Handbook of Endocrine Agents and Steroids. 1 November 2017. Taylor & Francis. 978-1-351-74347-1. 158–.
  2. Book: Horsky J, Presl J . Ovarian Function and its Disorders: Diagnosis and Therapy. 6 December 2012. Springer Science & Business Media. 978-94-009-8195-9. 93,318.
  3. Book: Challener CA . Chiral Drugs. 23 October 2017. Taylor & Francis. 978-1-351-80804-0. 1127–.
  4. Book: Horský J, Presl J . Ovarian Function and its Disorders. Hormonal Treatment of Disorders of the Menstrual Cycle. Developments in Obstetrics and Gynecology . 1981. 309–332. Springer . 10.1007/978-94-009-8195-9_11. 978-94-009-8197-3.
  5. Book: Greydanus DE . Contraception . Lavery JP, Sanfilippo JS . Pediatric and Adolescent Obstetrics and Gynecology. https://books.google.com/books?id=l9XTBwAAQBAJ&pg=PA236. 6 December 2012. Springer Science & Business Media. 978-1-4612-5064-7. 236–.
  6. Book: Kunz W . Über neue Arzneimittel . Denkewalter RG . Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques. https://books.google.com/books?id=ZSH3BwAAQBAJ&pg=PA407. 8 March 2013. Birkhäuser. 978-3-0348-7059-7. 407–.
  7. Hontela S . [Clinical Experience With the New Peroral Gestagen, 16-Methylene-6-Dehydro-17-Alpha-Acetoxyprogesterone (MDAP)] . de . Zentralblatt Fur Gynakologie . 86 . 1327–1332 . September 1964 . 14324038 .
  8. Králová A, Stĕrba R, Valová B . [Superlutin--a new Czechoslovak oral gestagen] . cs . Ceskoslovenska Gynekologie . 30 . 5 . 351–355 . June 1965 . 5835891 .
  9. Dvorák K, Presl J . [Biological testing of methenmadinone acetate (Superlutin Spofa) in clinical trials] . cs . Ceskoslovenska Gynekologie . 51 . 9 . 714–719 . November 1986 . 3539369 .
  10. Drázdil M . [Superlutin] . cs . Ceskoslovenska Farmacie . 15 . 10 . 543–544 . December 1966 . 5980773 .
  11. Horák C, Sedliak M . [Our experience in the treatment of menstruation disorders with Superlutin] . sk . Ceskoslovenska Gynekologie . 31 . 1 . 86–88 . February 1966 . 5932092 .
  12. Stĕrba R . [3-Methylether-ethinylestradiol (Mestranol) and 6-dehydro-16-methylene-17-alpha-acetoxyprogesterone (Superlutin) in the therapy of functional bleedings] . de . Zentralblatt Fur Gynakologie . 89 . 28 . 1030–1031 . July 1967 . 5586402 .
  13. Stĕrba R . [Some experiences with the effect of injectable progestational hormones] . Czech . Ceskoslovenska Gynekologie . 34 . 7 . 407–9 . September 1969 . 5809756 .
  14. Čekan Z, Šeda M, Mikulášková J, Syhora K . Steroid derivatives XXXIV. On the progestational activity of 6-dehydro-16-methylene-17α-acetoxyprogesterone . Steroids . 4 . 3 . 1964 . 415–42 1. 0039-128X . 10.1016/0039-128X(64)90154-0.
  15. Stĕrba R . [A Czechoslovak injection-contraceptive agent administered once a month] . de . Zentralblatt Fur Gynakologie . 98 . 3 . 158–160 . 1976 . 970015 .
  16. Toppozada MK . Existing once-a-month combined injectable contraceptives . Contraception . 49 . 4 . 293–301 . April 1994 . 8013216 . 10.1016/0010-7824(94)90029-9 .
  17. Book: Toppozada MK . Monthly Injectable Contraceptives . 93–103 . Goldsmith A, Toppozada M . Long-Acting Contraception . 1983 . 35018604 .
  18. Sterba R . 1968 . New biological application of contraceptive steroids. . Endocrinologia Experimentalis . 2 . 2 . 101–110 . https://web.archive.org/web/20180916202426/https://www.popline.org/node/469522 . 2018-09-16 .
  19. Melich H . [Biogest] ]. cs . Casopis Lekaru Ceskych . 111 . 30 . 694–695 . July 1972 . 5079918 . 2018-09-16 . dead . https://web.archive.org/web/20180916202203/https://www.popline.org/node/482986 . 2018-09-16 .
  20. Stĕrba R . [Towards a more physiological hormonal contraception] ]. de . Zentralblatt Fur Gynakologie . 92 . 10 . 303–312 . March 1970 . 4096927 . 2018-09-16 . dead . https://web.archive.org/web/20180916202323/https://www.popline.org/node/470458 . 2018-09-16 .
  21. Bekeová E, Krajnicáková M, Hendrichovský V, Maracek I . [Thyroid and ovarian hormones in ewes treated with gestagens and PMSG in the spring season] ]. sk . Veterinarni Medicina . 40 . 11 . 345–352 . November 1995 . 8659087 . 2018-09-16 . 2018-09-16 . https://web.archive.org/web/20180916202415/https://vetmed.vri.cz/?page=abstracts&detail=321 . dead .
  22. Book: Štěrba R . Current Problems in Fertility. On the Way to a More Physiological Hormonal Contraception. 1971. 154–158. Springer . 10.1007/978-1-4615-8651-7_28. https://www.popline.org/node/480951. 978-1-4615-8653-1. 2018-09-16. 2018-09-16. https://web.archive.org/web/20180916202608/https://www.popline.org/node/480951. dead.

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