Methdilazine Explained

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

See also

• Phenothiazine

References

• Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S . Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine . Microbiol Res . 160 . 1 . 95–100 . 2005 . 15782943 . 10.1016/j.micres.2004.10.002. free .
• Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R . Altered membrane permeability as the basis of bactericidal action of methdilazine . J Antimicrob Chemother . 42 . 1 . 83–6 . 1998 . 9700532 . 10.1093/jac/42.1.83. free .
• Chattopadhyay D, Dastidar S, Chakrabarty A . Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents . Arzneimittelforschung . 38 . 7 . 869–72 . 1988 . 2905130.

The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.