Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase explained

methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase
Ec Number:2.1.1.90
Cas Number:86611-98-5
Go Code:0047152

In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase is an enzyme that catalyzes the chemical reaction

methanol + 5-hydroxybenzimidazolylcobamide

\rightleftharpoons

Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

Further reading