Methallenestril Explained

Methallenestril (brand names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril), also known as methallenoestril and as methallenestrol, as well as Horeau's acid,^{[1] [2]} is a synthetic nonsteroidal estrogen and a derivative of allenolic acid and allenestrol (specifically, a methyl ether of it) that was formerly used to treat menstrual issues but is now no longer marketed.^{[3] [4] [5] [6]} It is a seco-analogue of bisdehydrodoisynolic acid, and although methallenestril is potently estrogenic in rats, in humans it is only weakly so in comparison.^[7] Vallestril was a brand of methallenestril issued by G. D. Searle & Company in the 1950s.^[8] Methallenestril is taken by mouth.^[9] By the oral route, a dose of 25 mg methallenestril is approximately equivalent to 1 mg diethylstilbestrol, 4 mg dienestrol, 20 mg hexestrol, 25 mg estrone, 2.5 mg conjugated estrogens, and 0.05 mg ethinylestradiol.

See also

• Carbestrol
• Fenestrel
• Doisynoestrol
• Doisynolic acid

Notes and References

1. Book: Heftmann E . Steroid Biochemistry. 1970. Academic Press. 144. 9780123366504.
2. Dodds EC . Synthetic oestrogens . The Journal of Pharmacy and Pharmacology . 1 . 3 . 137–147 . March 1949 . 18114509 . 10.1111/j.2042-7158.1949.tb12391.x . 221921908 . free .
3. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents. 21 November 1996. CRC Press. 978-0-412-46630-4. 1295–.
4. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 177–.
5. Book: Thomas JA, Keenan EJ . Estrogens and Estrogenic Compounds . Principles of Endocrine Pharmacology. https://books.google.com/books?id=mTagBQAAQBAJ&pg=PT136 . 1986 . Springer Science & Business Media. 978-1-4684-5036-1. 136.
6. Herbai G, Ljunghall S . Normalization of hypercalcaemia of primary hyperparathyroidism by treatment with methallenestril, a synthetic oestrogen with low oestrogenicity . Urologia Internationalis . 38 . 6 . 371–373 . 1983 . 6659184 . 10.1159/000280925 .
7. Book: Kirk RE, Othmer DF . Encyclopedia of chemical technology. 1980. Wiley. 978-0-471-02065-3. 670.
8. Book: Catalog of Copyright Entries: Third Series . 17 . Part 1, Number2 . July–December 1963 . Copyright Office, Library of Congress. 1984–.
9. Swyer GI . The oestrogens . British Medical Journal . 1 . 5128 . 1029–1031 . April 1959 . 13638626 . 1993181 . 10.1136/bmj.1.5128.1029 .