Metacycline Explained

Metacycline or methacycline is a tetracycline antibiotic. It is used as a precursor in the industrial synthesis of doxycycline hyclate.

It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro.^[1]

Notes and References

1. Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M . Identification of clinically used drugs that activate pregnane X receptors . Drug Metab. Dispos. . 39 . 1 . 151–9 . 2011 . 20966043 . 3014269 . 10.1124/dmd.110.035105 .