Metallocarboxypeptidase D Explained

Metallocarboxypeptidase D
Ec Number:3.4.17.22
Cas Number:153967-26-1

Metallocarboxypeptidase D (carboxypeptidase D (cattle, human, mouse, rat), gp180 (duck)) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Releases C-terminal Arg and Lys from polypeptides

This enzyme is activated by Co2+, and inhibited by guanidinoethylmercaptosuccinic acid.

Notes and References

  1. Kuroki K, Eng F, Ishikawa T, Turck C, Harada F, Ganem D . gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family . The Journal of Biological Chemistry . 270 . 25 . 15022–8 . June 1995 . 7797483 . 10.1074/jbc.270.25.15022 . free .
  2. Song L, Fricker LD . Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary . The Journal of Biological Chemistry . 270 . 42 . 25007–13 . October 1995 . 7559630 . 10.1074/jbc.270.42.25007 . free .
  3. Song L, Fricker LD . Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D . The Journal of Biological Chemistry . 271 . 46 . 28884–9 . November 1996 . 8910535 . 10.1074/jbc.271.46.28884 . free.

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