Metaescaline Explained

Metaescaline (3,4-dimethoxy-5-ethoxyphenethylamine) is a lesser-known psychedelic drug. It is an analog of mescaline. Metaescaline was first synthesized by Alexander Shulgin. In his book PiHKAL, the dosage range is listed as 200–350 mg, and the duration listed as 8–12 hours.^[1] Metaescaline produces mental insights, entactogenic, MDMA-like effects, and TOMSO-like activation. Little data exists about the pharmacological properties, metabolism, and toxicity of metaescaline, though it has been studied to a limited extent in comparison with other related compounds.^{[2] [3] [4]}

See also

• Substituted phenethylamine
• Phenethylamine
• Psychedelics, dissociatives and deliriants

Notes and References

1. http://www.erowid.org/library/books_online/pihkal/pihkal119.shtml Metaescaline entry in PiHKAL
2. Jacob P 3rd, Shulgin AT. Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues. J Med Chem. 1984 Jul;27(7):881-8.
3. Clare BW. Structure-activity correlations for psychotomimetics. 1. Phenylalkylamines: electronic, volume, and hydrophobicity parameters. J Med Chem. 1990 Feb;33(2):687-702.
4. Clare BW. The frontier orbital phase angles: novel QSAR descriptors for benzene derivatives, applied to phenylalkylamine hallucinogens. J Med Chem. 1998 Sep 24;41(20):3845-56.