Clear-cell carcinoma explained

Clear-cell carcinoma, also known as clear-cell adenocarcinoma and mesonephroma,^[1] is an epithelial-cell-derived carcinoma characterized by the presence of clear cells observed during histological, diagnostic assessment. This form of cancer is classified as a rare cancer with an incidence of 4.8% in white patients, 3.1% in black patients, and 11.1% in Asian patients.^[2] ^[3]

Clear-cell carcinoma may arise in multiple tissue types including the kidney (clear-cell renal-cell carcinoma), ovary (ovarian clear-cell carcinoma),^[4] uterus (uterine clear-cell carcinoma) or gastrointestinal tract (colorectal clear-cell carcinoma).^[5]

Treatment options for clear cell carcinoma vary by the tissue type affected. It may include a combination of chemotherapy (paclitaxel and carboplatin or irinotecan plus cisplatin) and surgical resection in ovarian clear-cell carcinoma; debulking or resection paired with chemotherapy (cisplatin) in ovarian clear-cell carcinoma; cytokine therapy (IL-2, interferon), kinase inhibitors (temsirolimus, sunitinib, sorafenib, pazopanib) and anti-angiogenic therapies (bevacizumab).

Notes and References

Web site: Clear cell carcinoma . NCI Dictionary of Cancer Terms . U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute (NCI) . 2011-02-02 .
Fujiwara K, Shintani D, Nishikawa T . Clear-cell carcinoma of the ovary . . 27 Suppl 1 . suppl_1 . i50–i52 . April 2016 . 27141072 . 10.1093/annonc/mdw086 . free .
Web site: Clear cell renal cell carcinoma . Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. Genetic and Rare Diseases Information Center (GARD), National Center for Advancing Translational Sciences (NCATS) . 2019-10-15.
Takano M, Tsuda H, Sugiyama T . Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? . . 31 . 1 . 53 . June 2012 . 22655678 . 3405444 . 10.1186/1756-9966-31-53 . free .
Remo A, Grillo F, Mastracci L, Fassan M, Sina S, Zanella C, Parcesepe P, Damiano Urso E, Pancione M, Bortuzzo G, Scarpa A, Manfrin E . 6 . Clear cell colorectal carcinoma: Time to clarify diagnosis . Pathology, Research and Practice . 213 . 5 . 447–452 . May 2017 . 28285963 . 10.1016/j.prp.2017.02.013 .