Meso-Butestrol Explained

meso-Butestrol (developmental code name SC-3402), also known as 2,3-bis(4-hydroxyphenyl)butane, is a synthetic nonsteroidal estrogen which was never marketed.^{[1] [2] [3] [4] [5] [6] [7]} It is a so-called "short-acting" or "impeded" estrogen. meso-Butestrol is structurally related to diethylstilbestrol and other stilbestrols.^[8] The fully potent counterpart to meso-butestrol is meso-hexestrol, analogously to the relationship of dimethylstilbestrol to diethylstilbestrol.

See also

• Butestrol

Notes and References

1. Miller BG, Emmens CW . The oestrogenic potency in the mouse of several substances closely related to diethylstilboestrol and meso-hexoestrol . J. Endocrinol. . 45 . 1 . 9–15 . September 1969 . 5347383 . 10.1677/joe.0.0450009 .
2. Terenius L . Two modes of interaction between oestrogen and anti-oestrogen . Acta Endocrinol. . 64 . 1 . 47–58 . May 1970 . 5468795 . 10.1530/acta.0.0640047 .
3. Terenius L . Structure-activity relationships of anti-oestrogens with regard to interaction with 17-beta-oestradiol in the mouse uterus and vagina . Acta Endocrinol. . 66 . 3 . 431–47 . March 1971 . 5107780 . 10.1530/acta.0.0660431 .
4. Terenius L . The Allen-Doisy test for estrogens reinvestigated . Steroids . 17 . 6 . 653–61 . June 1971 . 5104534 . 10.1016/0039-128x(71)90081-x .
5. Clark JH, Markaverich BM . The agonistic and antagonistic effects of short acting estrogens: a review . Pharmacol. Ther. . 21 . 3 . 429–53 . 1983 . 6356176 . 10.1016/0163-7258(83)90063-3 .
6. Lunan CB, Klopper A . Antioestrogens. A review . Clin. Endocrinol. (Oxf) . 4 . 5 . 551–72 . September 1975 . 170029 . 10.1111/j.1365-2265.1975.tb01568.x . 9628572 . free .
7. Martin L, Claringbold PJ . The mitogenic action of oestrogens in the vaginal epithelium of the ovariectomized mouse . J. Endocrinol. . 20 . 3. 173–86 . May 1960 . 14421704 . 10.1677/joe.0.0200173 .
8. Emmens CW, Cox RI, Martin L . The oestrogenic and anti-oestrogenic activity of compounds related to diethylstilboestrol . Acta Endocrinol. . 45 . 4_Suppl. SUPPL90:61–9 . 1964 . 14117596 . 10.1530/acta.0.045s061 .