Meprin B Explained

Meprin B
Ec Number:	3.4.24.63
Cas Number:	150679-52-0

Meprin B (meprin-b) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His⁵-Leu-, -Leu⁶-Cys-, -Ala¹⁴-Leu- and -Cys¹⁹-Gly- bonds in insulin B chain

Even though it is primarily found and embedded into the cell membrane it can also be found in the extracellular space.^[5] Like other meprins it can hydrolyze different molecules.

This membrane-bound metalloendopeptidase is present in mouse intestines.

Notes and References

1. Kounnas MZ, Wolz RL, Gorbea CM, Bond JS . Meprin-A and -B. Cell surface endopeptidases of the mouse kidney . The Journal of Biological Chemistry . 266 . 26 . 17350–7 . September 1991 . 1894622 .
2. Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS . Cloning, expression, and chromosomal localization of the mouse meprin beta subunit . The Journal of Biological Chemistry . 268 . 28 . 21035–43 . October 1993 . 8407940 .
3. Johnson GD, Hersh LB . Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation . The Journal of Biological Chemistry . 269 . 10 . 7682–8 . March 1994 . 7510289 .
4. Book: Wolz RL, Bond JS . Meprins A and B . Methods in Enzymology . 248 . 325–45 . 1995 . 7674930 . 10.1016/0076-6879(95)48022-6 .
5. Ishmael. Faoud T.. Shier. Vincent K.. Ishmael. Susan S.. Bond. Judith S.. February 2005. Intersubunit and Domain Interactions of the Meprin B Metalloproteinase DISULFIDE BONDS AND PROTEIN-PROTEIN INTERACTION IN THE MAM AND TRAF DOMAINS. Journal of Biological Chemistry. 280. 13895–13901.