(+)-Menthofuran synthase explained

(+)-Menthofuran synthase
Ec Number:	1.14.13.104

(+)-Menthofuran synthase (menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).^{[1] [2]} This enzyme catalyses the following chemical reaction

(+)-pulegone + NADPH + H⁺ + O₂

\rightleftharpoons (+)-menthofuran + NADP+ + H₂O

Menthofuran synthase is a heme-thiolate protein (P-450).

Notes and References

1. Bertea CM, Schalk M, Karp F, Maffei M, Croteau R . Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene . Archives of Biochemistry and Biophysics . 390 . 2 . 279–86 . June 2001 . 11396930 . 10.1006/abbi.2001.2378 .
2. Mahmoud SS, Croteau RB . Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase . Proceedings of the National Academy of Sciences of the United States of America . 100 . 24 . 14481–6 . November 2003 . 14623962 . 283617 . 10.1073/pnas.2436325100 . 2003PNAS..10014481M . free .