Melitracen Explained

Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety.^{[1] [2] [3] [4]} In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.^{[5] [6] [7] [8]}

The pharmacology of melitracen has not been properly investigated and is largely unknown, but it is likely to act in a similar manner to other TCAs. Indeed, melitracen is reported to have imipramine and amitriptyline-like effects and efficacy against depression and anxiety, though with improved tolerability and a somewhat faster onset of action.^{[9] [10]}

See also

• Fluotracen
• Litracen
• Dimetacrine

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 3-88763-075-0 .
2. Book: Dictionary of organic compounds . Chapman & Hall . London . 1996 . 0-412-54090-8 . Rhodes PH .
3. Book: O'Neil MJ . The Merck index: an encyclopedia of chemicals, drugs, and biologicals . Merck Research Laboratories . Rahway, NJ . 2001 . 0-911910-13-1 .
4. Book: Holenz J, Díaz JL, Buschmann H . Marketed Drugs and Drugs in DevelopmentVela . JM, Buschmann H, Holenz J, Párraga A, Torrens A . Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application . Wiley-VCH . Weinheim . 2007 . 978-3-527-31058-6 . https://books.google.com/books?id=yXD4QA-Y_Z0C&q=melitracen&pg=PA248.
5. Book: European Drug Index . 4th . CRC Press . Boca Raton . 1998 . 3-7692-2114-1 . Muller NF, Dessing RP .
6. Van Moffaert M, Dierick M, De Meulemeester F, Vereecken A . Treatment of depressive anxiety states associated with psychosomatic symptoms. A double-blind multicentre clinical study: mianserin versus melitracen-flupentixol . Acta Psychiatrica Belgica . 83 . 5 . 525–539 . 1983 . 6670581 .
7. Bin Yaacob H . Flupenthixol and Melitracen in the management of trigeminal neuralgia . Dental Journal of Malaysia . 8 . 2 . 37–38 . April 1985 . 3917005 .
8. Hashash JG, Abdul-Baki H, Azar C, Elhajj II, El Zahabi L, Chaar HF, Sharara AI . Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia . Alimentary Pharmacology & Therapeutics . 27 . 11 . 1148–1155 . June 2008 . 18331614 . 10.1111/j.1365-2036.2008.03677.x . vanc . 40714136 . free .
9. Book: Aronson JK . Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects) . Elsevier Science . Amsterdam . 2008 . 978-0-444-53266-4 .
10. Book: Krapcho J . Antidepressives and Stimulants . Annual Reports in Medicinal Chemistry . 5 . Academic Press . Boston . 1970 . 0-12-040505-9 . https://books.google.com/books?id=JIdV5T356CQC&q=melitracen&pg=PA13.