Melanoma inhibitory activity explained

Melanoma-derived growth regulatory protein is a protein that in humans is encoded by the MIA gene.^{[1] [2] [3]}

It is a marker for malignant melanoma.^[4]

Further reading

• Bosserhoff AK, Hein R, Bogdahn U, Buettner R . Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. . J. Biol. Chem. . 271 . 1 . 490–5 . 1996 . 8550608 . 10.1074/jbc.271.1.490 . free .
• Stoll R, Renner C, Zweckstetter M, etal . The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold. . EMBO J. . 20 . 3 . 340–9 . 2001 . 11157741 . 10.1093/emboj/20.3.340 . 133488.
• Lougheed JC, Holton JM, Alber T, etal . Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 10 . 5515–20 . 2001 . 11331761 . 10.1073/pnas.091601698 . 33244. 2001PNAS...98.5515L . free .
• Lougheed JC, Domaille PJ, Handel TM . Solution structure and dynamics of melanoma inhibitory activity protein. . J. Biomol. NMR . 22 . 3 . 211–23 . 2002 . 11991352 . 10.1023/A:1014961408029 . 8265482 .
• Hau P, Apfel R, Wiese P, etal . Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin. . Anticancer Res. . 22 . 2A . 577–83 . 2002 . 12014625 .
• Hau P, Wise P, Bosserhoff AK, etal . Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]. . J. Invest. Dermatol. . 119 . 3 . 562–9 . 2002 . 12230496 . 10.1046/j.1523-1747.2002.00501.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M. free .
• Poser I, Golob M, Buettner R, Bosserhoff AK . Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype. . Mol. Cell. Biol. . 23 . 8 . 2991–8 . 2003 . 12665595 . 10.1128/MCB.23.8.2991-2998.2003 . 152547.
• Callejo SA, Marshall JC, Cools-Lartigue J, etal . Macrophage-derived soluble factor enhances melanoma inhibitory activity expression by uveal melanoma cells in vitro. . Melanoma Res. . 14 . 2 . 91–5 . 2005 . 15057037 . 10.1097/00008390-200404000-00003 . 1429873 .
• Marr DG, Poser I, Shellman YG, etal . Ultraviolet radiation induces release of MIA: a new mechanism for UVR-induced progression of melanoma. . Int. J. Oncol. . 25 . 1 . 105–11 . 2005 . 15201995 . 10.3892/ijo.25.1.105.
• Poser I, Tatzel J, Kuphal S, Bosserhoff AK . Functional role of MIA in melanocytes and early development of melanoma. . Oncogene . 23 . 36 . 6115–24 . 2005 . 15208686 . 10.1038/sj.onc.1207797 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551.
• Jachimczak P, Apfel R, Bosserhoff AK, etal . Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques. . Int. J. Cancer . 113 . 1 . 88–92 . 2004 . 15386421 . 10.1002/ijc.20549 . 43308803 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Hau P, Ruemmele P, Kunz-Schughart LA, etal . Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma. . Oncol. Rep. . 12 . 6 . 1355–64 . 2005 . 15547763 . 10.3892/or.12.6.1355.
• Tatzel J, Poser I, Schroeder J, Bosserhoff AK . Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes. . Pigment Cell Res. . 18 . 2 . 92–101 . 2005 . 15760338 . 10.1111/j.1600-0749.2005.00212.x .
• Aung PP, Oue N, Mitani Y, etal . Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. . Oncogene . 25 . 17 . 2546–57 . 2006 . 16331256 . 10.1038/sj.onc.1209279 .
• Cao MG, Auge JM, Molina R, etal . Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma. . Anticancer Res. . 27 . 1B . 595–9 . 2007 . 17348447 .

Notes and References

1. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R, Bogdahn U . Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA . Cancer Res . 54 . 21 . 5695–701 . Nov 1994 . 7923218 .
2. Koehler MR, Bosserhoff A, von Beust G, Bauer A, Blesch A, Buettner R, Schlegel J, Bogdahn U, Schmid M . Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-q13.33 by fluorescence in situ hybridization (FISH) . Genomics . 35 . 1 . 265–7 . Sep 1996 . 8661134 . 10.1006/geno.1996.0352 .
3. Web site: Entrez Gene: MIA melanoma inhibitory activity.
4. Bosserhoff AK, Kaufmann M, Kaluza B, etal . Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma . Cancer Res. . 57 . 15 . 3149–53 . August 1997 . 9242442 .