Megazol Explained

Iupac Name:5-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazol-2-amine
Width:220
Cas Number:19622-55-0
Unii:VQ8UH664ZJ
Atc Prefix:None
Chemspiderid:27598
C:6
H:6
N:6
O:2
S:1
Smiles:Cn1c(cnc1c2nnc(s2)N)[N+](=O)[O-]

Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.

A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively. The drug is considerably more effective than standard benznidazole therapy (for Chagas) which is considered the gold standard.[1] This is despite that other nitroimidazoles proved ineffective against these pathogens.

Notes and References

  1. Hall BS, Wilkinson SR . Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation . Antimicrobial Agents and Chemotherapy . 56 . 1 . 115–23 . January 2012 . 22037852 . 3256028 . 10.1128/AAC.05135-11 .