Megakaryocyte–erythroid progenitor cell explained

Megakaryocyte–erythroid progenitor cells (MEPs), among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. Hematopoietic stem cells (HSC) can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. MEPs derive from the common myeloid progenitor lineage.[1] Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis.[2] [3] Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor cells.[4]

Notes and References

  1. Xavier-Ferrucio . Juliana . Krause . Diane S. . 2018-08-01 . Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies . Stem Cells . en . 36 . 8 . 1138–1145 . 10.1002/stem.2834 . 1066-5099 . 6105498 . 29658164.
  2. Shin . Eunju . Jeong . Jong-Gwan . Chung . Hyunmin . Jung . Haiyoung . Park . Charny . Yoon . Suk Ran . Kim . Tae-Don . Lee . Seung Jin . Choi . Inpyo . Noh . Ji-Yoon . 2020-07-12 . The Gata1low murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential . Biochemical and Biophysical Research Communications . en . 528 . 1 . 46–53 . 10.1016/j.bbrc.2020.04.143 . 32456797 . 218911834 . 0006-291X.
  3. Soares-da-Silva . Francisca . Freyer . Laina . Elsaid . Ramy . Burlen-Defranoux . Odile . Iturri . Lorea . Sismeiro . Odile . Pinto-do-Ó . Perpétua . Gomez-Perdiguero . Elisa . Cumano . Ana . 2021-04-05 . Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life . Journal of Experimental Medicine . en . 218 . 4 . e20201729 . 10.1084/jem.20201729 . 33566111 . 7879581 . 0022-1007.
  4. Psaila . Bethan . Mead . Adam J. . 2019-03-28 . Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation . Blood . en . 133 . 13 . 1427–1435 . 10.1182/blood-2018-11-835371 . 0006-4971 . 6443046 . 30728145.

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