Medrysone Explained

Medrysone (INN, USAN) (brand names HMS, Medrocort, others; former developmental code name NSC-63278), also known as hydroxymethylprogesterone, methylhydroxyprogesterone, or hydroxymesterone, as well as 6α-methyl-11β-hydroxyprogesterone or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases.^{[1] [2] [3]} It has been discontinued in the United States.^[4] Although it is very similar in structure to progesterone,^[5] neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.^{[6] [7] [8]}

Environmental presence

In 2021, medrysone was one of the 12 compounds identified in sludge samples taken from 12 wastewater treatment plants in California that were associated with estrogenic activity in in vitro. ^[9]

See also

• 9α-Bromo-11-ketoprogesterone
• 11β-Hydroxyprogesterone
• Endrisone
• Flugestone
• Fluorometholone

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 760–.
2. Book: Index Nominum 2000: International Drug Directory. January 2000. Taylor & Francis. 978-3-88763-075-1. 640–.
3. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 31 October 1999. Springer Science & Business Media. 978-0-7514-0499-9. 173–.
4. Web site: HMS - FDA prescribing information, side effects and uses.
5. Bedrossian RH, Eriksen SP . The treatment of ocular inflammation with medrysone . Archives of Ophthalmology . 81 . 2 . 184–191 . February 1969 . 5764682 . 10.1001/archopht.1969.00990010186008 .
6. Spaeth GL . Hydroxymethylprogesterone. An anti-inflammatory steroid without apparent effect on intraocular pressure . Archives of Ophthalmology . 75 . 6 . 783–787 . June 1966 . 5327794 . 10.1001/archopht.1966.00970050785014 .
7. Schwartz A, Leopold IH . Topical anti-inflammatory steroids and intraocular pressure: the place of medrysone . Drugs . 2 . 1 . 1–4 . 1971 . 5172545 . 10.2165/00003495-197102010-00001 . 37303359 .
8. Smolin G . Medrysone hypersensitivity. Report of a case . Archives of Ophthalmology . 85 . 4 . 478–479 . April 1971 . 5554878 . 10.1001/archopht.1971.00990050480015 .
9. Black GP, He G, Denison MS, Young TM . Using Estrogenic Activity and Nontargeted Chemical Analysis to Identify Contaminants in Sewage Sludge . Environmental Science & Technology . 55 . 10 . 6729–6739 . May 2021 . 33909413 . 8378343 . 10.1021/acs.est.0c07846 . 2021EnST...55.6729B .