Mecigestone Explained

Mecigestone, also known as pentarane B, as well as 6α-methyl-16α,17α-cyclohexanoprogesterone, 6α-methylcyclohexano[1',2';16,17]pregn-4-ene-3,20-dione, or 17α-acetyl-6α-methyl-16β,24-cyclo-21-norchol-4-en-3-one, is a steroidal progestin that was developed by the Zelinskii Institute of Organic Chemistry of the Russian Academy of Sciences and has been proposed for clinical use as a progestogen but has not been marketed.^{[1] [2] [3] [4] [5]} It is the 6α-methylated analogue of pentarane A, which is also known as D'6-pentarane or pregna-D'6-pentarane.

See also

• Acetomepregenol

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 8–.
2. Fedyushkina IV, Skvortsov VS, Romero Reyes IV, Levina IS . Molecular docking and 3D-QSAR of 16α,17α-cycloalkanoprogesterone derivatives as ligands of the progesterone receptor. Biochemistry (Moscow) Supplement Series B. 8. 2. 2014. 168–176. 1990-7508. 10.1134/S1990750814020048. 96191380.
3. Kamernitzky AV, Levina IS, Kulikova LE, Ignatov VN, Korkhov VV, Nikitina GV, Terekhina AI . Pregna-D'-pentaranes - a new class of active gestagenes . Journal of Steroid Biochemistry . 16 . 1 . 61–67 . January 1982 . 7062740 . 10.1016/0022-4731(82)90144-3 .
4. Nazarov AK, Zavarzin IV, Nazarov GV, Aksenov AV, Levina IS . Preparation and Bioavailability Evaluation of Micronized Steroidal Mecigestone Drug Substance. Pharmaceutical Chemistry Journal. 49. 10. 2016. 706–710. 0091-150X. 10.1007/s11094-016-1357-6. 6216213.
5. Bhakta A, Herman M, Levina IS, Moudgil VK . Interaction of cycloalkanoprogesterones with mammalian progesterone receptor: binding of pregna-D'-pentaranes in the calf uterine cytosol . Molecular and Cellular Biochemistry . 125 . 2 . 153–161 . August 1993 . 8283970 . 10.1007/BF00936444 . 20319611 .