Mdx mouse explained

The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD).^{[1] [2]} The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to STOP codon. This causes the muscle cells to produce a small, nonfunctional dystrophin protein.^[3] As a result, the mouse has a mild form of DMD where there is increased muscle damage and weakness.

Notes and References

1. PhD. University of Liverpool. Mechanisms skeletal muscle damage in the dystrophin-deficient MDX mouse. Anne.. McArdle. Anne McArdle. 1993. . 53496566.
2. 344791. 1984. Bulfield. G.. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 81. 4. 1189–1192. Siller. W. G.. Wight. P. A.. Moore. K. J.. 6583703. 1984PNAS...81.1189B. 10.1073/pnas.81.4.1189. free.
3. Web site: Animal Models - Parent Project Muscular Dystrophy. parentprojectmd.org. 2016-05-03.