Matriptase Explained

Matriptase
Ec Number:	3.4.21.109
Cas Number:	241475-96-7

Symbol:	S1A
Peptidase S1A, matripase
Interpro:	IPR017051
Membranome Family:	1287

Matriptases are an enzyme family.^{[1] [2]} This enzyme cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. It belongs to proteases of PA superfamily.

Human matriptases

• ST14, also known as matriptase
• TMPRSS6, also known as matriptase 2

Notes and References

1. Lee SL, Dickson RB, Lin CY . Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease . The Journal of Biological Chemistry . 275 . 47 . 36720–5 . November 2000 . 10962009 . 10.1074/jbc.M007802200 . free .
2. Lin CY, Anders J, Johnson M, Sang QA, Dickson RB . Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity . The Journal of Biological Chemistry . 274 . 26 . 18231–6 . June 1999 . 10373424 . 10.1074/jbc.274.26.18231 . free .