Mast cell sarcoma explained

Mast cell sarcoma
Specialty:Oncology
Onset:Can occur at any age.[1]
Prognosis:The median survival time is less than 18 months

Mast cell sarcoma is an extremely aggressive[2] form of sarcoma made up of neoplastic mast cells. A sarcoma is a tumor made of cells from connective tissue. Mast cell sarcoma is an extremely rare tumor. The largest analysis to date comprises 34 cases.[3] Prognosis is extremely poor. People with a mast cell sarcoma have no skin lesions, and pathology examination of the tumor shows it to be very malignant with an aggressive growth pattern.[4] Mast cell sarcoma should not be confused withextracutaneous mastocytoma, a rare benign mast cell tumor without destructive growth. In the cases observed, mast cell sarcoma terminated quickly as mast cell leukemia; one of the most aggressive human cancers.[5]

See also

Notes and References

  1. Monnier . Jilliana . Georgin-Lavialle . Sophie . Canioni . Danielle . Lhermitte . Ludovic . Soussan . Michael . Arock . Michel . Bruneau . Julie . Dubreuil . Patrice . Bodemer . Christine . Chandesris . Marie-Olivia . Lortholary . Olivier . Hermine . Olivier . Damaj . Gandhi . Mast cell sarcoma: new cases and literature review . Oncotarget . 4 October 2016 . 7 . 40 . 66299–66309 . 10.18632/oncotarget.11812 . 27602777 . 5323235 .
  2. Chott A, Guenther P, Huebner A, Selzer E, Parwaresch R, Horny H, Valent P . Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma . Am J Surg Pathol . 27 . 7 . 1013–9 . 2003 . 12826896 . 10.1097/00000478-200307000-00019. 46710032 .
  3. Matsumoto . Nana P. . Yuan . Ji . Wang . Jun . Shen . Qi . Chen . Xueyan . Kim . Young . Zuppan . Craig W. . Chang . Chung-Che . Cui . Wei . Chen . Dong . Shi . Min . Gisriel . Savanah D. . Chen . Mingyi . Xu . Mina L. . Pan . Zenggang . Mast cell sarcoma: clinicopathologic and molecular analysis of 10 new cases and review of literature . Modern Pathology . July 2022 . 35 . 7 . 865–874 . 10.1038/s41379-022-01014-w . 35105959 . free .
  4. Nancy Gould, "Diagnosis and Classification of Mastocytosis ", The Mastocytosis Society.
  5. Book: 10.1007/978-0-387-73744-7 . Rare Hematological Malignancies . 2008 . 978-0-387-73743-0 . Ansell . Stephen M. .

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