Mannosylglycerate synthase explained

Mannosylglycerate synthase
Ec Number:	2.4.1.269

Mannosylglycerate synthase is an enzyme with systematic name GDP-mannose:D-glycerate 2-alpha-D-mannosyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate

Depending on conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate.

See also

• EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase)
• EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase)

Notes and References

1. Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H . Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase . The Journal of Biological Chemistry . 274 . 50 . 35407–14 . December 1999 . 10585410 . 10.1074/jbc.274.50.35407 . free .
2. Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ . Structural dissection and high-throughput screening of mannosylglycerate synthase . Nature Structural & Molecular Biology . 12 . 7 . 608–14 . July 2005 . 15951819 . 10.1038/nsmb950 . Harry J. Gilbert . Gideon Davies .