Mannosylfructose-phosphate synthase explained

Mannosylfructose-phosphate synthase
Ec Number:2.4.1.246
Cas Number:92480-04-1 (not distinguished from EC 2.4.1.167)

Mannosylfructose-phosphate synthase (mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.[1] This enzyme catalyses the following chemical reaction

GDP-mannose + D-fructose 6-phosphate

\rightleftharpoons

GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity.

Notes and References

  1. Torres LL, Salerno GL . A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases . Proceedings of the National Academy of Sciences of the United States of America . 104 . 36 . 14318–23 . September 2007 . 17728402 . 1964871 . 10.1073/pnas.0706709104 . free .

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